First up is आप के साथ क्या नया हो रहा है , which translates roughly as "What's new with you?" Then there's आप के साथ और क्या चल रहा है, which is a cross between "What is going with you" and "What's going on?" We can throw a little past tense in there with आपने और क्या किया, loosely "What's happened with you?" Which leads me to our last and my favorite way to say "What's up?" क्या हाल है. It literally means "What's the situation?" or "What's the condition?" which always reminds me of The Big Lebowski, "Just Dropped In (To See What Condition My Condition Was In)."